Sartorius SECURA224-1S Manual and Replacement: Setup, isoCAL and the Quintix Pro QTX224IRU-1S

This Sartorius SECURA224-1S manual guide covers setup and isoCAL, and its replacement, the Sartorius Quintix Pro QTX224IRU-1S (220 g x 0.1 mg), is on sale for $3,999.00 (regular $5,560.00), in stock.

The Sartorius SECURA224-1S is a 220 g x 0.0001 g analytical balance from the Sartorius Secura line, with a glass draft shield, a 90 mm pan, a color touch screen, a Mini USB port, an electronic level indicator and isoCAL, the motorized internal calibration weight. Sartorius wrote one manual for Secura, Quintix and Practum, so owners have to pick the 224-1S numbers out of shared tables and skip the parts marked for other lines. Below are the SECURA224-1S figures from that manual for owners, then the balances we stock in its place. MNM Scales is an authorized Sartorius dealer.

SECURA224-1S replacement: what to buy now

The SECURA224-1S is no longer available from MNM Scales. Sartorius lists the Quintix Pro QTX224IRU-1S as its replacement, and we stock three more 220 g x 0.1 mg Sartorius balances. For prices across the range, see the Sartorius balance price guide; to choose between the two Entris II models, see Sartorius Entris II compared.

Model	Calibration	Display and ports	Good fit when
Quintix Pro QTX224IRU-1S	isoCAL internal	7-inch full-touch color screen; 3 USB-C, Ethernet, RS232	You want the direct SECURA224-1S replacement, guided leveling, user management and GLP/GMP printouts
Quintix QUINTIX224-1S	isoCAL internal	Color graphic display; USB and RS232	Your team already knows the Secura screens: it runs on the same WSE6004 manual
Entris II BCE224I-1S	isoCAL internal	LED with touch keys; RS232 and USB-C	You want automatic internal calibration with a simpler interface
Entris II BCE224-1S	External, 200 g E2 weight (not included)	LED with touch keys; RS232 and USB-C	You check with your own weights and want the simplest 0.1 mg setup

Moving from a SECURA224-1S, the QTX224IRU-1S and QUINTIX224-1S keep isoCAL and the 200 g external check, so your SOP changes least. The Entris II models have their own manual, explained in our Sartorius Entris II manual guide.

Sartorius SECURA224-1S manual: specifications

Item	SECURA224-1S
Capacity x readability	220 g x 0.1 mg (0.0001 g)
Repeatability (standard deviation)	0.1 mg
Linearity deviation	0.2 mg
Minimum initial weight per USP, typical	0.12 g
Sensitivity drift	±1.5 ppm per K (+10 to +30 °C)
Typical stabilization time	2 seconds
isoCAL triggers	Temperature change of 1.5 K, or every 4 hours, and after leveling
Pan and chamber	90 mm round pan; 209 mm from the pan to the upper draft shield panel
Net weight	About 5.1 kg
Power	Sartorius AC adapter YEPS01-PS4 (US plug), 100 to 240 V AC; balance draws about 4.5 W
Ambient range for the specifications	+10 to +30 °C, indoor use
Data port	Mini USB (SBI and xBPI protocols)
Weighing units	Gram, milligram, carat, pound, ounce, troy ounce, grain, pennyweight and more (depending on country version)

What comes in the box

• Balance, 90 mm weighing pan, pan support, shield plate and shield disk.
• Glass draft shield and the pan draft shield (Secura 0.1 mg models).
• AC adapter with country-specific plug adapters, in-use dust cover and dust cover.
• Installation and operating instructions and the application guide.
• Not included: the 200 g E2 calibration weight (Sartorius YCW522-AC-02), USB data cables, a printer and the YDK03 density kit. Keep the original packaging for shipping and mail-in service.

Setting up the SECURA224-1S

1. Unpack and inspect: check the balance for shipping damage right away and save all packaging. Do not ship it with cables plugged in.
2. Pick the spot: a stable, even bench free of vibration, such as a weighing stone, away from heaters, direct sun, drafts from windows, AC vents and doors, busy walkways, moisture and electromagnetic fields. Our balance table guide covers benches for 0.1 mg work.
3. Let it acclimatize: after bringing the balance in from a colder place, leave it unplugged for about two hours so no condensation forms.
4. Assemble the chamber with the balance unplugged: fit the in-use dust cover, unlock the draft shield, set it on the balance holding the top struts with both hands and the side doors pushed back, lock it, then fit the shield plate, shield disk, pan support, weighing pan and pan draft shield.
5. Power it: push the US plug adapter into the AC adapter until it clicks, connect the angle plug to the balance, then plug into the wall. Use only the Sartorius adapter.
6. Warm up for at least 30 minutes after first connecting power before you rely on the reading.
7. Run the startup wizard: on first power-on the balance asks for language, date format, date, time format and time, then opens the leveling screen.

Leveling with the electronic level indicator

Secura models check their position with sensors. When LEVEL shows in red at the top left of the screen, touch the LEVEL button. An animated level appears; turn the front leveling feet in the direction of the arrows until the animation turns green, then confirm. If you skip it, the prompt comes back every 2 minutes. Sartorius says to finish leveling by calibrating, and the SECURA224-1S starts isoCAL after each leveling. Level and calibrate again every time the balance is moved, and carry it by the housing, never by the draft shield.

SECURA224-1S calibration: isoCAL, CAL-Intern and CAL-Extern

The SECURA224-1S has a motorized internal weight, so it can adjust itself. For the trade-offs between internal and external weights, see internal vs external calibration balances.

isoCAL (automatic)

isoCAL runs when the temperature has changed by 1.5 K or 4 hours have passed since the last adjustment, and each time the balance is leveled. When it is due, a red isoCAL button appears. Set to Automatic, it starts on its own; set to Info, manual start, touch isoCAL to start it. If you dismiss it, the prompt returns 5 minutes later. Each adjustment and its deviation is saved on the balance as a report you can view in the settings or print.

CAL-Intern (manual, internal weight)

1. Make sure the balance is stable, the draft shield is closed and the pan is empty, then zero it.
2. Touch the menu key at the bottom left, then the CAL button. The Calibrate balance window opens.
3. Select CAL-Intern. The internal weight is placed, the balance is calibrated and adjusted, and the weight is removed.
4. Read the report (calibration deviation and adjustment deviation) and close it.

CAL-Extern (with a 200 g weight)

1. Empty the pan and zero the balance.
2. Open the menu, touch CAL and select CAL-Extern.
3. When prompted, place the calibration weight in the center of the pan. Calibration starts by itself.
4. Read the report and close it. Weight is too light! or Weight is too heavy! means the weight on the pan does not match what the balance expects.

Sartorius lists the 200 g Proof Line knob weight, OIML class E2 with a DAkkS certificate (YCW522-AC-02), for the 224 models. Note the tolerance of whatever weight you use. Our calibration weight classes guide explains E2 and F1, our calibration weights guide covers handling, and our how often should a scale be calibrated guide helps set a schedule.

SQmin minimum weighing and USP

SQmin is a Secura-only function. A service technician sets the minimum sample quantity from your QA rules and documents it in a weighing module test as per USP. When it is on, values below SQmin show in red and, depending on the safety level, cannot be saved or printed. SQmin is not the same as Min in legal metrology. The manual lists a typical USP minimum initial weight of 0.12 g for the 224-1S. Pharmacies can compare options in our pharmacy balance guide.

USB port and printing

The Mini USB port carries the SBI and xBPI protocols. With the Sartorius YCC04-D09 cable (not included) the balance can send values to a PC as spreadsheet or text format, or as a virtual COM port in PC-SBI and PC-xBPI modes after the driver is installed. It also works with Sartorius printers and, through YCC03-D09 or YCC03-D25 adapters, with 9-pin or 25-pin RS-232 devices. A non-Sartorius USB printer brings up The attached USB device is not supported. Our connect a scale to a computer guide covers the PC side.

SECURA224-1S status messages

Message	What it means
The balance needs to be leveled!	Run the LEVEL routine
The balance needs to be adjusted!	isoCAL is due
The balance needs to perform eCheck!	The internal self-test is due
Weight is too light! / Weight is too heavy!	Wrong weight on the pan during CAL-Extern
Maintenance interval ended	The service date set by a technician has passed
Cal. data not saved	The limit of 99 calibration records per day was reached
Value is too small! / Value is too large!	An entered value is out of range for that setting

If the reading drifts or will not settle, see our scale won’t zero or keeps drifting guide and the analytical balance preventive maintenance checklist.

Selling by weight: NTEP and the SECURA224-1S

The SECURA224-1S is the standard laboratory version and is non-NTEP. Need it legal for trade? Here is an NTEP alternative: Sartorius SECURA224-1NUS. NCWM lists the SECURA224-1NUS as accuracy Class I on Certificate of Conformance 21-013A1 (Secura Series), listed as Active on NCWM’s certificate search on November 4, 2026, with d = 0.1 mg and e = 1 mg. For selling by weight today, call us and we will match an NTEP model to your job. Our what is NTEP guide explains the classes.

Texas note: TDA does not require an NTEP certificate for every device, but the scale must meet NIST Handbook 44 and suit its use; some scales do need one, so we recommend NTEP models and can check yours. See TDA’s scales used in trade guidance (PDF) and our TDA scale certification guide, or call us or TDA to confirm your use.

Setup tips from our technicians

• Our TDA-registered technicians level, let isoCAL finish, then check with a 200 g E2 weight after every move.
• Give a balance that came in from a cold delivery van the full two hours unplugged, then the 30-minute warm-up.
• Leave isoCAL on Automatic unless your SOP says to start adjustments by hand.
• Use the same side door every time and let the reading settle with the doors closed.
• Handle the calibration weight with tweezers or gloves and keep it in its case.

Common mistakes we see

• Carrying the balance by the draft shield.
• Skipping the red LEVEL prompt, then wondering why results shift.
• Weighing before the 30-minute warm-up is over.
• Running CAL-Extern with a 100 g or F1 weight and getting Weight is too light!
• Touching the screen with a pen.

Calibration, repair and rentals from MNM Scales

• Book calibration: we calibrate the SECURA224-1S and its 0.1 mg replacements in-house with a certificate or a NIST-traceable certificate; call for a quote. See our balance calibration service in Houston, all tiers on the scale calibration service page, and NIST vs in-house certificates.
• Mail-in calibration: pack the balance in its original box with the draft shield, draft ring and pan removed, and ship it with the mail-in calibration service.
• Cypress pickup by appointment: drop off or pick up at our Cypress, TX shop (21249 FM 529 Rd, Cypress, TX 77433).
• On-site service: on-site calibration is $295 plus $2 per mile, round trip, once per visit, plus the calibration fee for each balance. Our TDA-registered technicians calibrate analytical balances in labs, QC rooms and pharmacies across the Houston area.
• Repair: touch screen, leveling sensor, adapter and weigh cell problems go to our scale repair bench.
• Rentals: ask about a scale rental while your SECURA224-1S is in for service.

Frequently asked questions

Where can I download the Sartorius SECURA224-1S manual?

Sartorius hosts the Secura, Quintix and Practum user manual, WSE6004, which covers the SECURA224-1S, as a PDF on its document hub. This guide collects the 224-1S numbers from it.

How do I calibrate the SECURA224-1S?

Zero the empty balance with the draft shield closed, open the menu, touch CAL and choose CAL-Intern to use the built-in weight. For an external check choose CAL-Extern and place a 200 g weight when prompted.

What is isoCAL on the SECURA224-1S?

isoCAL is the automatic adjustment with the internal weight. On the 224-1S it runs after a 1.5 K temperature change, every 4 hours, and after leveling, and it saves a report each time.

What calibration weight does the SECURA224-1S need?

Sartorius lists a 200 g OIML class E2 weight, YCW522-AC-02, for external calibration of the 224 models. It is not included with the balance.

What does a red LEVEL on the SECURA224-1S mean?

The balance is not level. Touch LEVEL and turn the front feet in the direction of the arrows until the animation turns green, then let it calibrate.

Is the SECURA224-1S still available?

Not from MNM Scales. Sartorius lists the Quintix Pro QTX224IRU-1S as the replacement for the SECURA224-1S, and we can calibrate and service the SECURA224-1S you already own.

What can I buy instead of the SECURA224-1S?

The Quintix Pro QTX224IRU-1S is the direct replacement. We also stock the QUINTIX224-1S, which uses the same WSE6004 manual, and the Entris II BCE224I-1S and BCE224-1S. All four weigh 220 g x 0.1 mg.

Is the SECURA224-1S NTEP approved?

No. The NTEP version is the SECURA224-1NUS, accuracy Class I on Certificate of Conformance 21-013A1.